ANTI-STARGAZIN/CACNG2; CT 100UG

Code: 07-577 D2-231

Analysis Note

ControlBrain tissue

Application

Research CategoryNeuroscience

This Anti-Stargazin/Cacng2 Antibody, CT is validated for use in...


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€630.00 EACH
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Analysis Note

ControlBrain tissue

Application

Research CategoryNeuroscience

This Anti-Stargazin/Cacng2 Antibody, CT is validated for use in IC, IP, WB for the detection of Stargazin/Cacng2.

Immunoprecipitation:
2-5 µg of this antibody has been reported by an independent laboratory to immunoprecipitate Stargazin in rat P2 lysate.

Research Sub CategorySynapse & Synaptic Biology

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Stargazin belongs to a group called voltage gated calcium channels (VGCCs) which are present in most excitable cells. Stargazin is thought to stabilize the calcium channel in an inactivated (closed) state.
There are five high voltage activated calcium channel types (L, N, P, Q, and R) and one low voltage activated channel type (T). Each of these channels exists as a heteromultimer of a1, b, a2/ d and g subunits with the voltage activated calcium channel function carried by the a subunits. VGCCs exert spatial and temporal control over cellular calcium concentrations and serve to modulate neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression, and neuronal survival.

Immunogen

KLH-conjugated, synthetic peptide corresponding to amino acids 305-323 (KDSKDSLHANTANRRTTPV) of rat Stargazin.

Epitope: C-terminus

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Protein A purified

Purified rabbit polyclonal IgG in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide before the addition of glycerol to 30%.

Format: Purified

Quality

Evaluated by western blot on RIPA lysates from rat brain microsomal preparation (Catalog # 12-144).

Western Blot Analysis:
0.5-2.0 µg/mL of this antibody detected Stargazin in RIPA lysates from rat brain microsomal preparation (Catalog # 12-144).

Specificity

Predicted to cross-react with mouse based on sequence similarity.

Recognizes Stargazin, MW ~36-39 kDa.

Storage and Stability

Stable for 1 year at -20°C from date of receipt.

Target description

~36-39 kDa

antibody formpurified antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
Gene Informationmouse ... Cacng2(12300)rat ... Cacng2(84347)
isotypeIgG
manufacturer/tradenameUpstate®
NCBI accession no.NP_006069
Quality Level100
shipped indry ice
species reactivityrat, mouse
technique(s)immunocytochemistry: suitable, western blot: suitable, immunoprecipitation (IP): suitable
UniProt accession no.Q9Y698
This product has met the following criteria to qualify for the following awards:



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